The microbiota–gut–brain Axis in psychiatric disorders

A Góralczyk-Bińkowska, D Szmajda-Krygier… - International journal of …, 2022 - mdpi.com
Modulating the gut microbiome and its influence on human health is the subject of intense
research. The gut microbiota could be associated not only with gastroenterological diseases …

Prenatal and perinatal risk and protective factors for psychosis: a systematic review and meta-analysis

C Davies, G Segre, A Estradé, J Radua… - The Lancet …, 2020 - thelancet.com
Background Prenatal and perinatal insults are implicated in the aetiopathogenesis of
psychotic disorders but the consistency and magnitude of their associations with psychosis …

Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk

AP Kępińska, CO Iyegbe, AC Vernon, R Yolken… - Frontiers in …, 2020 - frontiersin.org
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Childhood trauma in schizophrenia: current findings and research perspectives

D Popovic, A Schmitt, L Kaurani, F Senner… - Frontiers in …, 2019 - frontiersin.org
Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms
throughout adult life in most of the affected patients. This unfavorable course is associated …

Biological hypotheses, risk factors, and biomarkers of schizophrenia

Z Fišar - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Prenatal poly (i: C) exposure and other developmental immune activation models in rodent systems

U Meyer - Biological psychiatry, 2014 - Elsevier
It is increasingly appreciated that altered neuroimmune mechanisms might play a role in the
development of schizophrenia and related psychotic illnesses. On the basis of human …

Therapeutic potential of TAAR1 agonists in schizophrenia: evidence from preclinical models and clinical studies

N Dedic, H Dworak, C Zeni, G Rutigliano… - International Journal of …, 2021 - mdpi.com
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …

The immune system and developmental programming of brain and behavior

SD Bilbo, JM Schwarz - Frontiers in neuroendocrinology, 2012 - Elsevier
The brain, endocrine, and immune systems are inextricably linked. Immune molecules have
a powerful impact on neuroendocrine function, including hormone–behavior interactions …

Microglia are essential to masculinization of brain and behavior

KM Lenz, BM Nugent, R Haliyur… - Journal of …, 2013 - Soc Neuroscience
Brain sexual differentiation in rodents results from the perinatal testicular androgen surge. In
the preoptic area (POA), estradiol aromatized from testosterone upregulates the production …