The underlying neurobiological mechanisms of cannabidiol's (CBD) management of alcohol
use disorder (AUD) remains elusive. Aim We conducted a systematic review of …

N-acetyl cysteine (NAC) is a potent antioxidant that modulates glutamatergic signalling
which is thought to play a role in alcohol use disorder (AUD). There have been no clinical …

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central
nervous system (CNS). Most GABAergic neurons synthesize GABA from glutamate and …

The role of glutamate system in the etiology and pathophysiology of psychiatric disorders
has gained considerable attention in the past two decades, including dysregulation of the …

The surge in popularity of semaglutide (Ozempic, Wegovy, Rybelsus) and other glucagon-
like-peptide 1 (GLP-1) receptor agonists has been accompanied by widespread reports of …

Introduction and aims There is emerging evidence that heavy long‐term alcohol
consumption may alter the neuroimmune profile. We conducted a meta‐analysis of the …

Indirect evidence supports a link between disrupted serotonin (5-hydroxytryptamine; 5-HT)
signaling in the brain and addictive behaviors. However, the effects of hyposerotonergia on …

Aims Recent studies have suggested that females respond more favourably to baclofen
treatment for alcohol use disorder. Females are generally more likely to drink to regulate …

Objective Alcohol and other drug (AoD) use is a significant factor in the poor health status of
people in prison. Our aim is to explore associations of alcohol consumption with tobacco …

The GABA B agonist, baclofen, has been shown to reduce alcohol consumption in patients
with alcohol use disorder and also those with comorbid anxiety. This study aimed to …