Gut microbiota and cardiovascular disease

M Witkowski, TL Weeks, SL Hazen - Circulation research, 2020 - Am Heart Assoc
Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets

YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …

Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target

MH Janeiro, MJ Ramírez, FI Milagro, JA Martínez… - Nutrients, 2018 - mdpi.com
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …

ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities–role of gut microbiota dysbiosis

SD Viana, S Nunes, F Reis - Ageing research reviews, 2020 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …

Role of gut microbiota and their metabolites on atherosclerosis, hypertension and human blood platelet function: a review

AK Duttaroy - Nutrients, 2021 - mdpi.com
Emerging data have demonstrated a strong association between the gut microbiota and the
development of cardiovascular disease (CVD) risk factors such as atherosclerosis …

The relationship between choline bioavailability from diet, intestinal microbiota composition, and its modulation of human diseases

N Arias, S Arboleya, J Allison, A Kaliszewska… - Nutrients, 2020 - mdpi.com
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which, upon absorption by the host …

[HTML][HTML] Intestinal microbiome and fitness in kidney disease

B Meijers, P Evenepoel, HJ Anders - Nature reviews nephrology, 2019 - nature.com
Environmental changes can induce diversity shifts within ecosystems that affect interactions
between species. Similarly, the development of kidney disease induces shifts within the …

Total volatile basic nitrogen and trimethylamine in muscle foods: Potential formation pathways and effects on human health

AEDA Bekhit, SG Giteru, BWB Holman… - … Reviews in Food …, 2021 - Wiley Online Library
The use of total volatile basic nitrogen (TVB‐N) as a quality parameter for fish is rapidly
growing to include other types of meat. Investigations of meat quality have recently focused …

Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide

Y Zhu, Q Li, H Jiang - Apmis, 2020 - Wiley Online Library
The increasing prevalence of cardiovascular diseases cannot adequately be explained by
traditional risk factors. Recently, accumulating evidence has suggested that gut microbiota …

The specific alteration of gut microbiota in diabetic kidney diseases—a systematic review and meta-analysis

Y Wang, J Zhao, Y Qin, Z Yu, Y Zhang, X Ning… - Frontiers in …, 2022 - frontiersin.org
Background Emerging evidence indicates that gut dysbiosis is involved in the occurrence
and development of diabetic kidney diseases (DKD). However, the key microbial taxa …