Until recently, the use of preventative immunotherapy in neuromyelitis optica spectrum
disorders (NMOSD) was based on observational studies and clinical experiences …

Recent studies have demonstrated the importance of CD47 in protecting malignant B cells
from antibody dependent cellular phagocytosis (ADCP). Combined treatment of anti-CD47 …

Myasthenia gravis (MG) is an autoimmune neuromuscular disorder caused by
autoantibodies that disrupt neuromuscular transmission by targeting components of …

Multiple sclerosis (MS) is one of the common neurological disorders, with approximately 2.5
million confirmed cases worldwide. Its incidence, as a result of predisposal to etiological …

Organized into six parts, the book begins with a basic review of the immune system and
concepts for learning and treating neuroimmune conditions. The next four sections cover …

Multiple sclerosis is a complex disease with no definitive cause or cure. Positive clinical
trials such as those with anti-CD20 and negative clinical trials such as those with TACI-Ig–all …

Components of the immune system can impact diseases of the central nervous system
(CNS). This chapter is designed to introduce the reader to immunological discoveries that …

Mice transgenic for human CD19 have been an important animal model to help understand
the role of this molecule in B lymphocyte function. Previously, no lifetime studies had been …

Response to immunomodulatory therapies in myasthenia gravis (MG) can be variable. A
subset of MG patients remains refractory to conventional agents. B-cell targeted therapy with …

Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis. Each
disease is characterized by a diverse set of potential manifestations, which determine …