Covering: 2000 to 2023Cyanobacteria produce a variety of bioactive natural products that
can pose a threat to humans and animals as environmental toxins, but also have potential …

Natural products have been playing an indispensable role in drug discovery. However, it
seems that the golden period of discovering new compounds has passed since the first …

Animal cytoplasmic fatty acid synthase (FAS) represents a unique family of enzymes that are
classically thought to be most closely related to fungal polyketide synthase (PKS). Recently …

Genomics-guided methodologies have revolutionized the discovery of natural products.
However, a major challenge in the field of genome mining is determining how to selectively …

Abstract Background Orsellinic acid (2, 4-dihydroxy-6-methylbenzoic acid, OA) and its
structural analog o-Orsellinaldehyde, have become widely used intermediates in clinical …

Natural products biosynthesized from biocontrol fungi in the rhizosphere can have both
beneficial and deleterious effects on plants. Herein, we performed a comprehensive …

Filamentous fungi produce a very wide range of complex and often bioactive metabolites,
demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent …

Abstract Background Secondary metabolites (SMs) from mushroom-forming fungi
(Basidiomycota) and early diverging fungi (EDF) such as Mucoromycota are scarcely …

DNA-alkylating natural products play an important role in drug development due to their
significant antitumor activities. They usually show high affinity with DNA through different …

Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and
biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome …