In vitro selection of aptamers and their applications

MC DeRosa, A Lin, P Mallikaratchy… - Nature Reviews …, 2023 - nature.com
The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …

Anatomy of the antibody molecule

EA Padlan - Molecular immunology, 1994 - Elsevier
Anatomy of the antibody molecule - ScienceDirect Skip to main contentSkip to article Elsevier
logo Journals & Books Search RegisterSign in View PDF Download full issue Search …

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of …

Z Eshhar, T Waks, G Gross… - Proceedings of the …, 1993 - National Acad Sciences
The generation of tumor-specific lymphocytes and their use in adoptive immunotherapy is
limited to a few malignancies because most spontaneous tumors are very weak or not at all …

Humanized antibodies and methods for making them

PJ Carter, LG Presta - US Patent 6,054,297, 2000 - Google Patents
US6054297A - Humanized antibodies and methods for making them - Google Patents
US6054297A - Humanized antibodies and methods for making them - Google Patents …

Method for making humanized antibodies

PJ Carter, LG Presta - US Patent 6,407,213, 2002 - Google Patents
US6407213B1 - Method for making humanized antibodies - Google Patents US6407213B1 -
Method for making humanized antibodies - Google Patents Method for making humanized …

Immunotherapy: past, present and future

TA Waldmann - Nature medicine, 2003 - nature.com
Harnessing the immune system to treat chronic infectious diseases or cancer is a major goal
of immunotherapy. Among others, impediments to this aim include host failure to identify …

Quantum dots: synthesis, antibody conjugation, and HER2-receptor targeting for breast cancer therapy

I Fatima, A Rahdar, S Sargazi, M Barani… - Journal of functional …, 2021 - mdpi.com
Breast cancer is becoming one of the main lethal carcinomas in the recent era, and its
occurrence rate is increasing day by day. There are different breast cancer biomarkers, and …

Methods for producing members of specific binding pairs

J McCafferty, AR Pope, KS Johnson… - US Patent …, 2001 - Google Patents
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a
genetically diverse population of such sbp members in recombinant host cells in which the …

Antibodies with increased binding affinity

DA Scheinberg, CL Queen - US Patent 6,350,861, 2002 - Google Patents
The present invention provides methods for producing mutationally-altered
immunoglobulins and compositions containing such mutationally-altered immunoglobulins …

Antibody engineering

J Maynard, G Georgiou - Annual review of biomedical …, 2000 - annualreviews.org
▪ Abstract Antibodies are unique in their high affinity and specificity for a binding partner, a
quality that has made them one of the most useful molecules for biotechnology and …