Transforming growth factor–β1 in regulatory T cell biology
JM Moreau, M Velegraki, C Bolyard… - Science …, 2022 - science.org
Transforming growth factor–β1 (TGF-β1) is inextricably linked to regulatory T cell (Treg)
biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and …
biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and …
Reappraising the role of inflammation in heart failure
The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …
circulating levels of pro-inflammatory cytokines opened a new area of research that has …
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies
I Lurje, NT Gaisa, R Weiskirchen, F Tacke - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …
wound healing response and can occur in various organs such as the heart, lung, liver …
Macrophages in cardiac remodelling after myocardial infarction
J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature Reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …
Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level
M Rao, X Wang, G Guo, L Wang, S Chen, P Yin… - Basic research in …, 2021 - Springer
Inflammation and fibrosis are intertwined mechanisms fundamentally involved in heart
failure. Detailed deciphering gene expression perturbations and cell–cell interactions of …
failure. Detailed deciphering gene expression perturbations and cell–cell interactions of …
Hypertension: do inflammation and immunity hold the key to solving this epidemic?
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
Single-cell sequencing of mouse heart immune infiltrate in pressure overload–driven heart failure reveals extent of immune activation
Background: Inflammation is a key component of cardiac disease, with macrophages and T
lymphocytes mediating essential roles in the progression to heart failure. Nonetheless, little …
lymphocytes mediating essential roles in the progression to heart failure. Nonetheless, little …
T cells in fibrosis and fibrotic diseases
M Zhang, S Zhang - Frontiers in immunology, 2020 - frontiersin.org
Fibrosis is the extensive deposition of fibrous connective tissue, and it is characterized by
the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is …
the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is …
Proteomic evaluation of the comorbidity-inflammation paradigm in heart failure with preserved ejection fraction: results from the PROMIS-HFpEF study
S Sanders-van Wijk, J Tromp, L Beussink-Nelson… - Circulation, 2020 - Am Heart Assoc
Background: A systemic proinflammatory state has been hypothesized to mediate the
association between comorbidities and abnormal cardiac structure/function in heart failure …
association between comorbidities and abnormal cardiac structure/function in heart failure …
Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited
therapeutic options and poorly understood immune pathophysiology. Using a 2-hit …
therapeutic options and poorly understood immune pathophysiology. Using a 2-hit …