Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Stress activates multiple neural and endocrine systems to allow an animal to respond to and
survive in a threatening environment. The corticotropin-releasing factor system is a primary …

Over the last decade, there has been increased interest in the role of the gut microbiome in
health including brain health. This is by no means a new theory; Elie Metchnikoff proposed …

The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

The gut microbiota, via the production of metabolites entering the circulation, plays a role in
blood pressure regulation. Blood pressure is also affected by the characteristics of sleep. To …

In recent decades, there has been a growing interest in investigating the effects of chronic
and acute stress on cognitive processes, especially memory performance. However …

Background: The chronic stress of social isolation is a valid predictor of cognitive pathology.
This study aimed to compare the effects of long-term social isolation on female versus male …

Impaired mitochondrial function and abnormalities in the tryptophan (Trp)-kynurenine (Kyn)
pathway are linked to age-related mood disorders. This study investigated the effect of …

Little is known about age differences in the effects of stress on memory retrieval. Our aim
was to perform an in-depth examination of acute psychosocial stress effects on memory …

The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by
acting as a general regulator of protein homeostasis. The major route of Trp degradation, the …