Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events.
It involves the interaction of different physiological systems at varying degrees of activity …

Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Frailty is an emerging global health burden, with major implications for clinical practice and
public health. The prevalence of frailty is expected to rise alongside rapid growth in the …

Background Physical frailty and sarcopenia show extensive clinical similarities. Whether
biomarkers exist that are shared by the two conditions is presently unclear. Methods We …

Objective Physical or mental imbalance caused by harmful stimuli can induce stress to
maintain homeostasis. During chronic stress, the sympathetic nervous system is …

Stress can influence health throughout the lifespan, yet there is little agreement about what
types and aspects of stress matter most for human health and disease. This is in part …

Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …

Abstract Adverse Childhood Experiences (ACEs) are stressful and/or traumatic experiences
associated with an increased lifetime risk of negative health outcomes. The Allostatic Load …

Allostatic load reflects the cumulative effects of stressful experiences in daily life and may
lead to disease over time. When the cost of chronic exposure to fluctuating or heightened …

For the last five decades, science has managed to delineate the mechanisms by which
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …