Effect of tertiary lymphoid structures on prognosis of patients with hepatocellular carcinoma and preliminary exploration of its formation mechanism

J Li, Y Nie, W Jia, W Wu, W Song, Y Li - Cancers, 2022 - mdpi.com
Simple Summary At present, research on tertiary lymphoid structures (TLSs) in
hepatocellular carcinoma (HCC) has been limited to the prognostic impact. Our manuscript …

Low-dose radiotherapy promotes the formation of tertiary lymphoid structures in lung adenocarcinoma

D Wang, L Huang, D Qian, Y Cao, X Wu, P Xu… - Frontiers in …, 2024 - frontiersin.org
Purpose A tertiary lymphoid structure (TLS) refers to an organized infiltration of immune cells
that is linked to a positive prognosis and improved response to immunotherapy. However …

Mechanisms of tertiary lymphoid structure formation: cooperation between inflammation and antigenicity

S Khanal, A Wieland, AJ Gunderson - Frontiers in immunology, 2023 - frontiersin.org
To mount an effective anti-tumor immune response capable of controlling or eliminating
disease, sufficient numbers of lymphocytes must be recruited to malignant tissue and …

A review of compartmentalised inflammation and tertiary lymphoid structures in the pathophysiology of multiple sclerosis

R Kee, M Naughton, GV McDonnell, OW Howell… - Biomedicines, 2022 - mdpi.com
Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central
nervous system (CNS). The most common form of MS is a relapsing–remitting disease …

Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

A Vaccaro, T van de Walle, M Ramachandran… - Frontiers in …, 2023 - frontiersin.org
Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in
association with chronic inflammation or cancer. Mature TLS are organized into B and T cell …

[HTML][HTML] Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer

NH Ruddle - Current Opinion in Physiology, 2023 - Elsevier
High endothelial venules (HEVs), high walled cuboidal blood vessels, through their
expression of adhesion molecules and chemokines, allow the entrance of lymphoid cells …

Neoadjuvant systemic therapy for hepatocellular carcinoma

RC Chick, SM Ruff, TM Pawlik - Frontiers in immunology, 2024 - frontiersin.org
Surgical resection and liver transplant remain the only curative therapies for most patients
with hepatocellular carcinoma (HCC). Systemic therapy options have typically been …

Tertiary lymphoid structures: Associated multiple immune cells and analysis their formation in hepatocellular carcinoma

Y Nie, H Fan, J Li, X Lei, T Zhang, Y Wang… - The FASEB …, 2022 - Wiley Online Library
The prognostic value of immune cells in tertiary lymphoid structures (TLSs) remains unclear
in hepatocellular carcinoma (HCC). Here, 59 of 145 patients had TLSs in training set, 48 of …

Characterization of estrogen receptors in pancreatic adenocarcinoma with tertiary lymphoid structures

X Zou, Y Liu, X Lin, R Wang, Z Dai, Y Chen, M Ma… - Cancers, 2023 - mdpi.com
Simple Summary The role of estrogen signaling in pancreatic adenocarcinoma (PAAD) was
unclear. Here we investigated the expression patterns of three estrogen receptors (ERα …

The role of dendritic cells in radiation-induced immune responses

AP Kaur, A Alice, MR Crittenden, MJ Gough - International Review of Cell …, 2023 - Elsevier
Dendritic cells perform critical functions in bridging innate and adaptive immunity. Their
ability to sense adjuvant signals in their environment, migrate on maturation, and cross …