Simple Summary The tumor immune microenvironment is an important area of tumor
research. Tertiary lymphoid structures, as a specific component of this, have recently begun …

Immunotherapy shows substantial advancement in cancer and is becoming widely used in
clinical practice. A variety of biomarkers have been proposed to predict the efficacy of …

Tertiary lymphoid structures (TLS) represent the ectopic aggregations of immune cells
arising during chronic inflammation or tumor progression. In cancer, TLS are often …

The NK cell is an important component of the tumor microenvironment of pancreatic ductal
adenocarcinoma (PDAC), also plays a significant role in PDAC development. This study …

Background Neoadjuvant chemoimmunotherapy has offered novel therapeutic options for
patients with locally advanced oesophageal squamous cell carcinoma (ESCC). Depicting …

Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed at advanced stages and
associated with early distant metastasis and poor survival. Besides clinical factors, the tumor …

Pancreatic adenocarcinoma (PDAC) is an aggressive tumor with poor survival and limited
treatment options. PDAC resistance to immunotherapeutic strategies is multifactorial, but …

Despite the efforts, pancreatic ductal adenocarcinoma (PDAC) is still highly lethal.
Therapeutic challenges reside in late diagnosis and establishment of peculiar tumor …

Tertiary lymphoid structures (TLS) can reflect cancer prognosis and clinical outcomes in
various tumour tissues. Tumour-associated macrophages (TAMs) are indispensable …

The humoral response mediated by alloantibodies directed against donor HLA molecules
(DSAs) is one of the main causes of graft loss in kidney transplantation. Understanding the …