Genomic analysis and filtration of novel prognostic biomarkers based on metabolic and immune subtypes in pancreatic cancer

G Chen, Y Liu, D Su, J Qiu, J Long, F Zhao, J Tao… - Cellular Oncology, 2023 - Springer
Purpose Patients with pancreatic cancer (PC) can be classified into various molecular
subtypes and benefit from some precise therapy. Nevertheless, the interaction between …

[HTML][HTML] Translational learnings in the development of chemo-immunotherapy combination to bypass the cold tumor microenvironment in pancreatic ductal …

H Kaplon - Frontiers in Oncology, 2022 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with a 5-year
relative survival rate of 5%. The desmoplastic stroma found in the tumor microenvironment of …

[HTML][HTML] SWI/SNF chromatin remodelers in prostate cancer progression

SC Ordonez-Rubiano, BP Strohmier, S Sood… - … in Epigenetics and …, 2024 - frontiersin.org
Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most
common cause of cancer-related deaths in men in the US. The majority of PCa cases arise …

食管鳞癌中三级淋巴结构的表达特征及临床意义

李梅, 王燕妮, 陈曦, 杨会杰, 岳文彬 - 肿瘤综合治疗电子杂志, 2023 - jmcm2018.com
目的主要评估三级淋巴结构(tertiary lymphatic structure, TLS) 在食管鳞状细胞癌(简称食管鳞癌
) 中的分布特点, 并分析TLS 与临床病理特征和预后的相关性, 为食管癌精准治疗提供新的思路 …

[HTML][HTML] Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy

Z Lin, Y Wu, XG Xiao, X Zhang, J Wan, T Zheng… - Frontiers in …, 2022 - frontiersin.org
Background: CAMP response element binding protein 3-like 1 (CREB3L1) has been
indicated as a critical biomarker and can modulate multifaced behaviors of tumor cells in …

Impact of tertiary lymphoid structures on prognosis and therapeutic response in pancreatic ductal adenocarcinoma

N Merali, MD Jessel, EH Arbe-Barnes, WYR Lee… - HPB, 2024 - Elsevier
Background Pancreatic ductal adenocarcinoma (PDAC) is known to have a heterogeneous
desmoplastic tumour microenvironment (TME) with a large number of immunosuppressive …

Multi-resolution deep learning characterizes tertiary lymphoid structures in solid tumors

M van Rijthoven, S Obahor, F Pagliarulo, M Broek… - bioRxiv, 2023 - biorxiv.org
Tertiary lymphoid structures (TLSs) are dense accumulations of lym-phocytes in inflamed
peripheral tissues, including cancer, and are associated with improved survival and …

[HTML][HTML] Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE2-dependent IgE inhibition in pancreatic cancer

L De Monte, F Clemente, E Ruggiero, R Pini… - …, 2023 - thelancet.com
Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and it is
characterized by predominant pro-tumor Th2-type inflammation. T follicular helper (Tfh) cells …

A case of adrenal undifferentiated pleomorphic sarcoma with tertiary lymphoid structures responded to pembrolizumab

H Kokubun, T Kijima, A Takada‐Owada… - IJU Case …, 2023 - Wiley Online Library
Introduction Although undifferentiated pleomorphic sarcomas are aggressive, a subset of
these tumors are immunogenic and may respond to immunotherapy. Case presentation A …

FAK inhibiteur et chimiothérapie: une nouvelle stratégie prometteuse pour les patients atteints de cancer pancréatique

I Belhabib - 2023 - theses.hal.science
Les chimiothérapies atteignent la tumeur par le système vasculaire, faisant de la quantité et
la qualité des vaisseaux sanguins un régulateur clé de l'efficacité des drogues. Or, dans …