Aberrant crypt foci (ACF) are the earliest visible neoplastic lesions in the colorectum. The
natural history of these lesions and their role in the adenoma-carcinoma sequence are …

It is believed that sessile serrated adenomas/polyps lead to the development of
microsatellite unstable cancer via a dysplasia-carcinoma sequence. Little is known …

Colorectal cancer (CRC) presents in three major forms: inherited, sporadic, and familial.
Although the mechanisms underlying familial CRC are poorly understood, a large body of …

Background and aims: Probe-based confocal laser endomicroscopy (pCLE; Cellvizio,
Mauna Kea Technologies, Paris, France) enables in vivo histology during colonoscopy and …

Objective To clarify of the features of sessile serrated adenoma/polyp (SSA/P) observed with
image-enhanced endoscopy using immunohistochemical staining. Materials and methods …

Background KRAS and BRAF mutations appear of relevance in the genesis and progression
of several solid tumor types but the co-occurrence and interaction of these mutations have …

Serrated polyps of the colorectum form a group of related lesions which include aberrant
crypt foci (ACF), conventional hyperplastic polyps, mixed (admixed) polyps, serrated …

Ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor that shows
puzzling histologic features encompassing metaplastic and neoplastic nature. This type of …

Advanced colorectal polyps are identified based on size≥ 10 mm, high-grade dysplasia,
and/or villous histology. A diagnosis of tubular adenoma (TA) is recommended if villous …

Aims: Cyclin D1 and cyclin‐dependent kinases are commonly activated in colorectal cancer.
Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important …