Colorectal cancer (CRC) results from a stepwise accumulation of genetic and epigenetic
alterations that transform the normal colonic epithelium into cancer. DNA methylation …

Background: Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon
cancer with microsatellite instability (MSI). However, the developmental mechanism of …

The serrated neoplasia pathway accounts for 20–30% of colorectal cancers (CRC), which
are characterized by extensive methylation (CpG island methylation phenotype, CIMP) …

Background and Aims Sessile serrated adenoma/polyps (SSA/Ps), which are precursor
lesions of colorectal cancer (CRC) with BRAF mutation and the CpG island methylator …

Background. The efficacy of colonoscopy in detecting abnormalities within the colon is
highly dependent on the adequacy of the bowel preparation. The objective of this study was …

The benign serrated architecture of the hyperplastic polyp has now been recognized in
morphologically similar lesions with potential for transformation to colorectal carcinoma: the …

It is believed that sessile serrated adenomas/polyps lead to the development of
microsatellite unstable cancer via a dysplasia-carcinoma sequence. Little is known …

Herein, we describe the clinical, pathologic, immunohistochemical, and molecular features
of 3 unique patients with long standing inflammatory bowel disease, all of whom developed …

On its discovery in 1965 by Gold and Freedman 1 in the blood of patients with colorectal
cancer, human carcinoembryonic antigen [CEA (since re-designated CEACAM5)] was …

Aberrant crypt foci (ACF) are the earliest visible neoplastic lesions in the colorectum. The
natural history of these lesions and their role in the adenoma-carcinoma sequence are …