[HTML][HTML] Rational use of inhaled corticosteroids for the treatment of COPD

JK Quint, A Ariel, PJ Barnes - npj Primary Care Respiratory Medicine, 2023 - nature.com
Inhaled corticosteroids (ICS) are the mainstay of treatment for asthma, but their role in
chronic obstructive pulmonary disease (COPD) is debated. Recent randomised controlled …

Inhaled phosphodiesterase inhibitors for the treatment of chronic obstructive pulmonary disease

D Singh, S Lea, AG Mathioudakis - Drugs, 2021 - Springer
Phosphodiesterase (PDE) 4 inhibitors prevent the metabolism of cyclic adenosine
monophosphate, thereby reducing inflammation. Inhaled PDE4 inhibitors aim to restrict …

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of …

L Carzaniga, ID Linney, A Rizzi… - Journal of Medicinal …, 2022 - ACS Publications
The development of molecules embedding two distinct pharmacophores acting as
muscarinic antagonists and β2 agonists (MABAs) promises to be an excellent opportunity to …

[HTML][HTML] Airway bacteria quantification using polymerase chain reaction combined with neutrophil and eosinophil counts identifies distinct COPD endotypes

A Beech, S Lea, J Li, N Jackson, A Mulvanny, D Singh - Biomedicines, 2021 - mdpi.com
Background: Chronic obstructive pulmonary disease (COPD) inflammatory endotypes are
associated with different airway microbiomes. We used quantitative polymerase chain …

[HTML][HTML] Effective Component Compatibility of Bufei Yishen Formula III Which Regulates the Mucus Hypersecretion of COPD Rats via the miR-146a-5p/EGFR/MEK …

J Ma, X Liu, Y Wei, R Lu, K Xu, Y Tian, J Li - … and Alternative Medicine, 2022 - hindawi.com
Background. The effective-component compatibility of Bufei Yishen formula III (ECC-BYF III)
with 5 ingredients (ginsenoside Rh1, astragaloside, icariin, nobiletin, and paeonol) has …

[PDF][PDF] Epidemiological burden, risk factors, and recent therapeutic advances in chronic obstructive pulmonary disease

BL Ayilya, RA Nazeer - J Adv Biotechnol Exp Ther, 2023 - academia.edu
Chronic obstructive pulmonary disease (COPD) is a progressive disease that is certainly
preventable and treatable and is caused due to the continuous exposure to noxious …

[HTML][HTML] Analysis of the clinical efficacy and molecular mechanism of xuefu zhuyu decoction in the treatment of COPD based on meta-analysis and network …

Y Hu, Y Lan, Q Ran, Q Gan, W Huang - … and Mathematical Methods …, 2022 - hindawi.com
Background. Chronic obstructive pulmonary disease (COPD) is becoming a major public
health burden worldwide. It is urgent to explore more effective and safer treatment strategy …

The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease

S Li, L Lin, J Zhao, Z Yang, Y Zhong… - COPD: Journal of …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis
is influenced by genetic factors. This study aimed to evaluate the role of IL5RA genetic …

[HTML][HTML] Chronic obstructive pulmonary disease: the present and future

A Krishnan, AM Turner - Biomedicines, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition associated
with smoking and is predicted to become a leading cause of death in the current decade [1] …

[HTML][HTML] Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9

W Zhu, L Han, Y Wu, L Tong, L He, Q Wang, Y Yan… - Respiratory …, 2023 - Springer
Background Chronic obstructive pulmonary disease (COPD), a chronic inflammatory lung
disease, is a leading cause of morbidity and mortality worldwide. Prolonged cigarette …