[HTML][HTML] An insight into modern targeted genome-editing technologies with a special focus on CRISPR/Cas9 and its applications

F Akram, S Sahreen, F Aamir, I Haq, K Malik… - Molecular …, 2023 - Springer
Genome-editing technology has enabled scientists to make changes in model organisms'
DNA at the genomic level to get biotechnologically important products from them. Most …

[HTML][HTML] Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

LY Zhou, YH Zhu, XY Wang, C Shen, XW Wei… - Computational and …, 2020 - Elsevier
Zwitterions consist of equal molar cationic and anionic moieties and thus exhibit overall
electroneutrality. Zwitterionic materials include phosphorylcholine, sulfobetaine …

Progress in the application of 3D-printed sodium alginate-based hydrogel scaffolds in bone tissue repair

X Hu, Z Zhang, H Wu, S Yang, W Zhao, L Che… - Biomaterials …, 2023 - Elsevier
In recent years, hydrogels have been widely used in the biomedical field as materials with
excellent bionic structures and biological properties. Among them, the excellent …

A review on advanced CRISPR-based genome-editing tools: base editing and prime editing

A Saber Sichani, M Ranjbar, M Baneshi… - Molecular …, 2023 - Springer
In the field of medicine, it is axiomatic that the need of a precise gene-editing tool is critical to
employ therapeutic approaches toward pathogenic mutations, occurring in human genome …

[HTML][HTML] Atomic-scale insights into allosteric inhibition and evolutional rescue mechanism of Streptococcus thermophilus Cas9 by the anti-CRISPR protein AcrIIA6

X Li, C Wang, T Peng, Z Chai, D Ni, Y Liu… - Computational and …, 2021 - Elsevier
CRISPR-Cas systems are prokaryotic adaptive immunity against invading phages and
plasmids. Phages have evolved diverse protein inhibitors of CRISPR-Cas systems, called …

[HTML][HTML] Recent advances in genome editing of stem cells for drug discovery and therapeutic application

J Lee, D Bayarsaikhan, G Bayarsaikhan, JS Kim… - Pharmacology & …, 2020 - Elsevier
Genome engineering technologies right from viral vector-mediated to protein-based editing—
which include zinc finger nucleases, TALENs, and CRISPR/Cas systems—have been …

[HTML][HTML] CRISPR/Cas9 and nanotechnology pertinence in agricultural crop refinement

BJ Naik, G Shimoga, SC Kim, M Manjulatha… - Frontiers in Plant …, 2022 - frontiersin.org
The CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-
associated protein 9) method is a versatile technique that can be applied in crop refinement …

Translating CRISPR-Cas therapeutics: approaches and challenges

LS Tay, N Palmer, R Panwala, WL Chew… - The CRISPR …, 2020 - liebertpub.com
CRISPR-Cas clinical trials have begun, offering a first glimpse at how DNA and RNA
targeting could enable therapies for many genetic and epigenetic human diseases. The …

relevant conditions and pathology of laboratory mice, rats, gerbils, Guinea pigs, hamsters, naked mole rats, and rabbits

TK Cooper, DK Meyerholz, AP Beck, MA Delaney… - ILAR …, 2021 - academic.oup.com
Animals are valuable resources in biomedical research in investigations of biological
processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and …

[HTML][HTML] CRISPR technology in gene-editing-based detection and treatment of SARS-CoV-2

B Shademan, A Nourazarian, S Hajazimian… - Frontiers in Molecular …, 2022 - frontiersin.org
Outbreak and rapid spread of coronavirus disease (COVID-19) caused by coronavirus acute
respiratory syndrome (SARS-CoV-2) caused severe acute respiratory syndrome (SARS-CoV …