Since its first clinical description (on his son) by William James West (1793–1848) in 1841,
and the definition of the classical triad of (1) infantile spasms;(2) hypsarrhythmia, and (3) …

Objective Numerous genetic testing options for individuals with epilepsy have emerged over
the past decade without clear guidelines regarding optimal testing strategies. We performed …

Abstract The International League Against Epilepsy (ILAE) Task Force on Nosology and
Definitions proposes a classification and definition of epilepsy syndromes in the neonate …

Children with infantile spasms are likely to have a poor outcome. Outcome measures for
infantile spasms include primary response to treatment, relapse of spasms, neurological …

Objective To identify whether abnormal electroencephalography (EEG) connectivity is
present before the onset of epileptic spasms (ES) in infants with tuberous sclerosis complex …

Precision medicine is an old concept, but it is not widely applied across human health
conditions as yet. Numerous attempts have been made to apply precision medicine in …

Objective Genetic variants in the SCN8A gene underlie a wide spectrum of
neurodevelopmental phenotypes including several distinct seizure types and a host of …

Objective Neuroimaging and genetic testing have been proposed for diagnostic evaluation
of infantile spasms (IS), establishing etiology in~ 60% of multicenter IS cohorts. A …

Objective Literature on the genotypic spectrum of Infantile Epileptic Spasms Syndrome
(IESS) in children is scarce in developing countries. This multicentre collaboration evaluated …

Objective To compare the therapeutic effectiveness of oral corticosteroids with that of
adrenocorticotrophic hormone for infantile spasms. Methods PubMed, Embase, Scopus, and …