Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles

P Møller, PH Danielsen, DG Karottki, K Jantzen… - … research/Reviews in …, 2014 - Elsevier
Generation of oxidatively damaged DNA by particulate matter (PM) is hypothesized to occur
via production of reactive oxygen species (ROS) and inflammation. We investigated this …

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation

HM Braakhuis, MVDZ Park, I Gosens… - Particle and fibre …, 2014 - Springer
The increasing manufacture and use of products based on nanotechnology raises concerns
for both workers and consumers. Various studies report induction of pulmonary inflammation …

Outdoor air pollution and new-onset airway disease. An official American Thoracic Society workshop report

GD Thurston, JR Balmes, E Garcia… - Annals of the …, 2020 - atsjournals.org
Although it is well accepted that air pollution exposure exacerbates preexisting airway
disease, it has not been firmly established that long-term pollution exposure increases the …

A critical review of approaches and limitations of inhalation bioavailability and bioaccessibility of metal (loid) s from ambient particulate matter or dust

F Kastury, E Smith, AL Juhasz - Science of the total environment, 2017 - Elsevier
Inhalation of metal (loid) s in ambient particulate matter (APM) represents a significant
exposure pathway to humans. Although exposure assessment associated with this pathway …

Air pollution and cardiovascular injury: epidemiology, toxicology, and mechanisms

BZ Simkhovich, MT Kleinman, RA Kloner - Journal of the American College …, 2008 - jacc.org
Recent epidemiologic studies show that increased levels of air pollutants are positively
associated with cardiovascular morbidity and mortality. Inhalation of air pollutants affects …

The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter

R Miyata, SF van Eeden - Toxicology and applied pharmacology, 2011 - Elsevier
Emerging epidemiological evidence suggests that exposure to particulate matter (PM) air
pollution increases the risk of cardiovascular events but the exact mechanism by which PM …

Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies

S Becker, S Mundandhara, RB Devlin… - Toxicology and applied …, 2005 - Elsevier
In order to better understand how ambient air particulate matter (PM) affect lung health, the
two main airway cell types likely to interact with inhaled particles, alveolar macrophages …

Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs

MP Holsapple, WH Farland, TD Landry… - Toxicological …, 2005 - academic.oup.com
This article summarizes a roundtable discussion held at the 2005 Society of Toxicology
Annual Meeting in New Orleans, LA. The purpose of the roundtable was to review the …

Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters

JR Swiston, W Davidson, S Attridge… - European respiratory …, 2008 - Eur Respiratory Soc
Epidemiological studies report an association between exposure to biomass smoke and
cardiopulmonary morbidity. The mechanisms for this association are unclear. The aim of the …

Cardiovascular toxicity of different sizes amorphous silica nanoparticles in rats after intratracheal instillation

Z Du, D Zhao, L Jing, G Cui, M Jin, Y Li, X Liu… - Cardiovascular …, 2013 - Springer
The purpose of this work was to investigate the cardiovascular toxicity of different sizes and
different dosages of silica nanoparticles in Wistar rats. The three silica nanoparticles (30, 60 …