Collagen remodeling along cancer progression providing a novel opportunity for cancer diagnosis and treatment
K Song, Z Yu, X Zu, G Li, Z Hu, Y Xue - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …
main component of the ECM, are greatly remodeled alongside cancer development. More …
Targeting type I collagen for cancer treatment
R Shi, Z Zhang, A Zhu, X Xiong, J Zhang… - … Journal of Cancer, 2022 - Wiley Online Library
Collagen is the most abundant protein in animals. Interactions between tumor cells and
collagen influence every step of tumor development. Type I collagen is the main fibrillar …
collagen influence every step of tumor development. Type I collagen is the main fibrillar …
DNMT1 facilitates growth of breast cancer by inducing MEG3 hyper-methylation
X Zhu, L Lv, M Wang, C Fan, X Lu, M Jin, S Li… - Cancer cell …, 2022 - Springer
Background To understand the effect of DNMT1-mediated MEG3 promoter methylation on
breast cancer progression. Methods Expression of DNMT1, MEG3 and miR-494-3p was …
breast cancer progression. Methods Expression of DNMT1, MEG3 and miR-494-3p was …
Collagen prolyl 4-hydroxylases modify tumor progression
Collagen is the main component of the extracellular matrix. Hydroxylation of proline residues
on collagen, catalyzed by collagen prolyl 4-hydroxylase (C-P4H), is essential for the stability …
on collagen, catalyzed by collagen prolyl 4-hydroxylase (C-P4H), is essential for the stability …
DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in …
Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is
upregulated in various human cancers, including colorectal cancer (CRC). This study …
upregulated in various human cancers, including colorectal cancer (CRC). This study …
The BRD9/7 inhibitor TP-472 blocks melanoma tumor growth by suppressing ECM-mediated oncogenic signaling and inducing apoptosis
Simple Summary Melanoma is an aggressive form of skin cancer and the leading cause of
skin cancer-related deaths. Current therapies, including those targeting oncogenic pathways …
skin cancer-related deaths. Current therapies, including those targeting oncogenic pathways …
Experimental murine models for colorectal cancer research
Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it
metastasizes, it has dramatic consequences. Murine models in CRC research are important …
metastasizes, it has dramatic consequences. Murine models in CRC research are important …
TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status
S Agarwal, M Behring, HG Kim… - Molecular …, 2020 - Wiley Online Library
Overexpression of TRIP13, a member of the AAA‐ATPase family, is linked with various
cancers, but its role in metastasis is unknown in colorectal cancer (CRC). In the current …
cancers, but its role in metastasis is unknown in colorectal cancer (CRC). In the current …
[HTML][HTML] Identification of a novel glycolysis-related gene signature for predicting the prognosis of osteosarcoma patients
M Yang, X Ma, Z Wang, T Zhang, Y Hua, Z Cai - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Glycolysis ensures energy supply to cancer cells, thereby facilitating tumor progression.
Here, we identified glycolysis-related genes that could predict the prognosis of patients with …
Here, we identified glycolysis-related genes that could predict the prognosis of patients with …
Strategies for efficient targeting of tumor collagen for cancer therapy
Simple Summary The tumor microenvironment encompasses the cellular and extracellular
matrix components that support and shape the three-dimensional framework in which solid …
matrix components that support and shape the three-dimensional framework in which solid …