Current concepts of psoriasis immunopathogenesis
Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the
skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is …
skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is …
Update on psoriasis immunopathogenesis and targeted immunotherapy
Over recent years, significant progress has been made in characterisation of the underlying
pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with …
pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with …
[HTML][HTML] Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
FO Nestle, C Conrad, A Tun-Kyi, B Homey… - The Journal of …, 2005 - ncbi.nlm.nih.gov
Psoriasis is one of the most common T cell–mediated autoimmune diseases in humans.
Although a role for the innate immune system in driving the autoimmune T cell cascade has …
Although a role for the innate immune system in driving the autoimmune T cell cascade has …
Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL …
C Tillack, LM Ehmann, M Friedrich, RP Laubender… - Gut, 2014 - gut.bmj.com
Background We analysed incidence, predictors, histological features and specific treatment
options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions …
options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions …
Antimicrobial peptides in the pathogenesis of psoriasis
S Morizane, RL Gallo - The Journal of dermatology, 2012 - Wiley Online Library
One characteristic abnormality of lesional skin in psoriasis is the excessive production of
antimicrobial peptides and proteins (AMPs). AMPs typically are small (12–50 amino acids) …
antimicrobial peptides and proteins (AMPs). AMPs typically are small (12–50 amino acids) …
Type I interferon: potential therapeutic target for psoriasis?
Y Yao, L Richman, C Morehouse, M de los Reyes… - PloS one, 2008 - journals.plos.org
Background Psoriasis is an immune-mediated disease characterized by aberrant epidermal
differentiation, surface scale formation, and marked cutaneous inflammation. To better …
differentiation, surface scale formation, and marked cutaneous inflammation. To better …
[HTML][HTML] Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Th17 pathways
E Rácz, EP Prens, D Kurek, M Kant, D De Ridder… - Journal of Investigative …, 2011 - Elsevier
Narrow-band ultraviolet-B (NB-UVB) phototherapy is an effective treatment for psoriasis. The
molecular mechanisms underlying its efficacy are incompletely understood. To identify NB …
molecular mechanisms underlying its efficacy are incompletely understood. To identify NB …
Induction of clinical autoimmune disease by therapeutic interferon-α
C Gota, L Calabrese - Autoimmunity, 2003 - Taylor & Francis
Much progress has been made in our understanding of Interferon biology since its initial
description by Isaacs and Lindenmann in 1957.[1] Type I Interferons have well established …
description by Isaacs and Lindenmann in 1957.[1] Type I Interferons have well established …
Psoriasis: from pathogenesis to novel therapeutic approaches
G Monteleone, F Pallone, TT MacDonald… - Clinical …, 2011 - portlandpress.com
Psoriasis is one of the commonest chronic inflammatory disorders. Its cause is unknown, but
a wealth of studies indicate that the disease results from a complex and dynamic interplay …
a wealth of studies indicate that the disease results from a complex and dynamic interplay …
Psoriasis induced by topical imiquimod
JK Wu, G Siller, G Strutton - Australasian journal of dermatology, 2004 - Wiley Online Library
We report the provocation of localized psoriasis at the sites of application of topical
imiquimod, possibly evolving into a generalized flare. A patient with pre‐existing psoriasis …
imiquimod, possibly evolving into a generalized flare. A patient with pre‐existing psoriasis …