Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

The biological action of androgens is mediated through the androgen receptor (AR).
Androgen-bound AR functions as a transcription factor to regulate genes involved in an …

Multiple myeloma (MM) is a B cell malignancy resulting in osteolytic lesions and fractures. In
the disease state, bone healing is limited owing to increased osteoclastic and decreased …

Cancer cells are characterized by a higher rate of protein turnover and greater demand for
protein homeostasis compared to normal cells. In this scenario, the ubiquitin–proteasome …

We tested the hypothesis that myocyte loss in failing human hearts occurs by different
mechanisms: apoptosis, oncosis, and autophagic cell death. Explanted hearts from 19 …

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates,
suggesting an intimate connection between injured brain and loss of proteostasis …

This text presents contemporary analytical techniques for the determination of heavy metals
in air particles, water, soil and biological samples. It details experimental studies to reduce …

Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

We have shown that activation of nuclear factor-κB (NF-κB) promotes cell survival and
expression of cytokines such as growth-regulated oncogene-α, which can modulate …