Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

While activating antitumor immunity with toll-like receptor (TLR) agonists provides a
promising approach toward cancer immunotherapy, existing TLR agonists, including …

Background In the tumor microenvironment (TME), tumor-associated macrophages (TAMs)
play a key immunosuppressive role that limits the ability of the immune system to fight …

Cancer immunotherapy has emerged as a promising strategy to treat cancer patients.
Among the wide range of immunological approaches, cancer vaccines have been …

Tumors intricately shape a highly immunosuppressive microenvironment, hampering
effective antitumor immune responses through diverse mechanisms. Consequently …

Tumour-associated macrophages (TAMs) sustain a tumour-supporting and
immunosuppressive milieu and therefore aggravate cancer prognosis. To modify TAM …

Oncolytic bacteria are a classification of bacteria with a natural ability to specifically target
solid tumors and, in the process, stimulate a potent immune response. Currently, these …

Background Toll-like receptor 8 (TLR8) can recognize specific pathogen-associated
molecular patterns and exert multiple immunological functions through activation of …

Lung cancer remains the most common cause of cancer death. Given the continued
research into new drugs and combination therapies, outcomes in lung cancer have been …