Various research groups around the world are actively investigating cardiovascular
prostheses of biological origin. This review article discusses the need for such bioprosthetics …

Decades of research have been undertaken towards the goal of tissue engineering using
xenogeneic scaffolds. The primary advantages associated with use of xenogeneic tissue …

Objective: To compare survival and outcome in patients receiving a mechanical or
bioprosthetic heart valve prosthesis. Design: Randomised prospective trial. Setting: Tertiary …

Calcification is the principal cause of failure of tissue-derived cardiac valve replacements
pretreated with glutaraldehyde (GLUT). The objective of this study was to determine the role …

A review of articles published since 1979 indicates that thrombotic and bleeding
complications account for about 50% of valve-related complications in patients with …

The elastic response of aortic valve cusps is a summation of its fibrous components. To
investigate the micromechanical function of valve leaflet constituents, we separated the …

Predilection of certain sites of the porcine bioprosthetic valve (PBV) leaflets to calcification
and tissue disruption has provoked suggestions that design factors and mechanical stresses …

Background. One factor influencing the choice of mechanical versus bioprosthetic valves is
reoperation for bioprosthetic valve failure. To define its operative risk, we reviewed our …

Mechanical Prosthetic Heart Valves 1. Long-term (permanent) warfarin therapy offers the
most consistent protection. 2. Doses of warfarin that increase the PT ratio to an INR greater …

Primary tissue failure (structural valve deterioration) has been documented as the most
prominent complication of porcine bioprostheses. The influence of age on primary tissue …