[PDF][PDF] Ferroptosis: principles and significance in health and disease
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …
peroxidation, is governed by molecular networks involving diverse molecules and …
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer
J Ma, J Zhao, Z Wu, J Tan, M Xu, W Ye… - …, 2024 - academic.oup.com
Nucleotide metabolism is the ultimate and most critical link in the self-replication process of
tumors, including gastric cancer (GC). However, in clinical treatment, classic anti-tumor …
tumors, including gastric cancer (GC). However, in clinical treatment, classic anti-tumor …
A Photoactivatable Upconverting Nanodevice Boosts Lysosomal Escape of PROTAC Degraders for Enhanced Combination Therapy
J Zhan, X Li, Y Mu, H Yao, JJ Zhu, J Zhang - Biomaterials Science, 2024 - pubs.rsc.org
PROteolysis TArgeting Chimeras (PROTACs) have received increasing attention due to their
capability to induce potent degradation of various disease-related proteins. However, the …
capability to induce potent degradation of various disease-related proteins. However, the …
Expanding TPD Horizons: Innovative Strategies Targeting BCL6 and SMARCA2
RB Kargbo - ACS Medicinal Chemistry Letters, 2024 - ACS Publications
Targeted protein degradation (TPD) technologies represent a groundbreaking approach in
cancer therapy, focusing on the selective degradation of oncogenic proteins such as BCL6 …
cancer therapy, focusing on the selective degradation of oncogenic proteins such as BCL6 …
Transforming Therapeutic Approaches with PROTAC Technology: New Targets and Potentials
RB Kargbo - ACS Medicinal Chemistry Letters, 2024 - ACS Publications
This Patent Highlight delves into the ground-breaking impact of Proteolysis Targeting
Chimeras (PROTACs) on targeted protein degradation, offering novel strategies to eliminate …
Chimeras (PROTACs) on targeted protein degradation, offering novel strategies to eliminate …
Lysosomal Degradation of Extracellular Targets: Innovations and Implications
RB Kargbo - ACS Medicinal Chemistry Letters, 2024 - ACS Publications
The therapeutic landscape is experiencing a significant transformation with the development
of strategies focused on the lysosomal degradation of extracellular targets. This innovative …
of strategies focused on the lysosomal degradation of extracellular targets. This innovative …