Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Fibroblasts and macrophages are present in all tissues, and mounting evidence supports
that these cells engage in direct communication to influence the overall tissue …

Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the
pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease
characterised by fibrosis of the lung parenchyma and loss of lung function. Although the …

The objective of the present study was to identify biological signatures of severe coronavirus
disease 2019 (COVID-19) predictive of admission in the intensive care unit (ICU). Over 170 …

Ontologically distinct populations of macrophages differentially contribute to organ fibrosis
through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing …

Diabetes-associated morbidity and mortality is predominantly due to complications of the
disease that may cause debilitating conditions, such as heart and renal failure, hepatic …

Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic …

Macrophages are found in close proximity with collagen-producing myofibroblasts and
indisputably play a key role in fibrosis. They produce profibrotic mediators that directly …