Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis
L Wang, C He - Frontiers in immunology, 2022 - frontiersin.org
Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …
main innate immune effector cells triggering the initial inflammatory responses in the …
Regulation of PD-L1 Expression by NF-κB in Cancer
F Antonangeli, A Natalini, MC Garassino… - Frontiers in …, 2020 - frontiersin.org
Immune checkpoints are inhibitory receptor/ligand pairs regulating immunity that are
exploited as key targets of anti-cancer therapy. Although the PD-1/PD-L1 pair is one of the …
exploited as key targets of anti-cancer therapy. Although the PD-1/PD-L1 pair is one of the …
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the
majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant …
majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant …
Targeting transcription factors for cancer treatment
M Lambert, S Jambon, S Depauw… - Molecules, 2018 - mdpi.com
Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …
which they account for about 20% of all oncogenes identified so far. For long time, with the …
Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke
Neuroinflammation is initiated in response to ischemic stroke, generally with the hallmarks of
microglial activation and collateral brain injury contributed by robust inflammatory effects …
microglial activation and collateral brain injury contributed by robust inflammatory effects …
GLUT1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy
PB Ancey, C Contat, G Boivin, S Sabatino, J Pascual… - Cancer research, 2021 - AACR
Neutrophils are the most abundant circulating leucocytes and are essential for innate
immunity. In cancer, pro-or antitumor properties have been attributed to tumor-associated …
immunity. In cancer, pro-or antitumor properties have been attributed to tumor-associated …
Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …
regulation of a large number of genes that are involved in important physiological …
Inflammation, NF-κB, and chronic diseases: how are they linked?
AB Kunnumakkara, B Shabnam, S Girisa… - Critical Reviews™ in …, 2020 - dl.begellhouse.com
Most chronic diseases, caused by lifestyle factors, appear to be linked to inflammation.
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …
Inflammation is activated mechanistically, and nuclear factor-κB (NF-κB) is a significant …
[HTML][HTML] Revisiting of TAMs in tumor immune microenvironment: Insight from NF-κB signaling pathway
R He, Y He, R Du, C Liu, Z Chen, A Zeng… - Biomedicine & …, 2023 - Elsevier
Tumor-associated macrophages (TAMs) are key components of tumor immune
microenvironment and play a dual role in promoting tumor growth and anti-tumor immunity …
microenvironment and play a dual role in promoting tumor growth and anti-tumor immunity …
The role of the transcription factor nuclear factor-kappa B in thyroid autoimmunity and cancer
C Giuliani, I Bucci, G Napolitano - Frontiers in endocrinology, 2018 - frontiersin.org
Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that is involved in
inflammatory and immune responses, as well as in regulation of expression of many other …
inflammatory and immune responses, as well as in regulation of expression of many other …