Most cardiomyopathies are familial diseases. Cascade family screening identifies
asymptomatic patients and family members with early traits of disease. The inheritance is …

The development of the reprogramming technology led to generation of induced Pluripotent
Stem Cells (iPSC) from a variety of somatic cells. Ever since, fast growing knowledge of …

Background: BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS
probands have genetically identified pathogenic variants. Recent evidence has implicated …

Genetic studies in the 1980s and 1990s led to landmark discoveries that sarcomere
mutations cause both hypertrophic and dilated cardiomyopathies. Sarcomere mutations also …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a leading cause of
sudden cardiac death, but its progression over time and predictors of arrhythmias are still …

Cardiomyopathies (ie, diseases of the heart muscle) are major causes of morbidity and
mortality. A significant percentage of patients with cardiomyopathies have genetic-based …

Background—Mutations in genes encoding for desmosomal proteins are the most common
cause of arrhythmogenic right ventricular cardiomyopathy (ARVC). We assessed the value …

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a rare inherited
heart muscle disease characterized by ventricular tachyarrhythmia, predominant right …

Abstract Sudden death accounts for 300,000-400,000 deaths annually in the United States.
Most sudden deaths are cardiac, and most sudden cardiac deaths are related to arrhythmias …