The Multifunctional Family of Mammalian Fatty Acid–Binding Proteins

J Storch, B Corsico - Annual review of nutrition, 2023 - annualreviews.org
Fatty acid–binding proteins (FABPs) are small lipid-binding proteins abundantly expressed
in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have …

Uncertainties in Markov state models of small proteins

N Kozlowski, H Grubmüller - Journal of Chemical Theory and …, 2023 - ACS Publications
Markov state models are widely used to describe and analyze protein dynamics based on
molecular dynamics simulations, specifically to extract functionally relevant characteristic …

Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes

JM Gullett, MG Cuypers, CR Grace, S Pant… - Journal of Biological …, 2022 - ASBMB
Fatty acid (FA) transfer proteins extract FA from membranes and sequester them to facilitate
their movement through the cytosol. Detailed structural information is available for these …

Ligand entry into fatty acid binding protein via local unfolding instead of gap widening

T Xiao, Y Lu, J Fan, D Yang - Biophysical journal, 2020 - cell.com
Fatty acid binding proteins play an important role in the transportation of fatty acids. Despite
intensive studies, how fatty acids enter the protein cavity for binding is still controversial …

Capturing the Effects of Single Atom Substitutions on the Inhibition Efficiency of Glycogen Synthase Kinase-3β Inhibitors via Markov State Modeling and Experiments

R Mehrani, J Mondal, D Ghazanfari… - Journal of Chemical …, 2024 - ACS Publications
Small modifications in the chemical structure of ligands are known to dramatically change
their ability to inhibit the activity of a protein. Unraveling the mechanisms that govern these …

On the Dynamic Mechanism of Long-Flexible Fatty Acid Binding to Fatty Acid Binding Protein: Resolving the Long-Standing Debate

H Chen, Y Guo, S Ye, J Zhang, H Zhang… - Journal of Chemical …, 2023 - ACS Publications
Fatty acids (FAs) are one of the essential energy sources for physiological processes, and
they play a vital role in regulating immune and inflammatory responses, promoting cell …

Dissecting the Protein Dynamics Coupled Ligand Binding with Kinetic Models and Single-Molecule FRET

S Wu, W Zhang, W Li, W Huang, Q Kong, Z Chen… - Biochemistry, 2022 - ACS Publications
Protein–ligand interactions are crucial to many biological processes. Ligand binding and
dissociation are the basic steps that allow proteins to function. Protein conformational …

Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

S Ruskamo, OC Krokengen, J Kowal… - Journal of Biological …, 2020 - ASBMB
Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family
that functions in the formation and maintenance of the peripheral nerve myelin sheath …

Fatty acid and retinol-binding protein: unusual protein conformational and cavity changes dictated by ligand fluctuations

GP Barletta, G Franchini, B Córsico… - Journal of Chemical …, 2019 - ACS Publications
Lipid-binding proteins (LBPs) are soluble proteins responsible for the uptake, transport, and
storage of a large variety of hydrophobic lipophilic molecules including fatty acids, steroids …

Lipid exchange in crystal‐confined fatty acid binding proteins: X‐ray evidence and molecular dynamics explanation

HA Alvarez, A Cousido‐Siah… - Proteins: Structure …, 2023 - Wiley Online Library
Fatty acid binding proteins (FABPs) are responsible for the long‐chain fatty acids (FAs)
transport inside the cell. However, despite the years, since their structure is known and the …