Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with human complex traits. However, the genes or functional DNA elements …

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P< 2.2× 10− 7); of …

In this volume of the IJE, Gao and colleagues explore the causal effect of adiposity on
several cancers using twosample Mendelian randomization (MR), and find some evidence …

Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …

The global epidemic of obesity is a major public health problem today. Obesity increases the
risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain …

Importance In observational studies, abdominal adiposity has been associated with type 2
diabetes and coronary heart disease (CHD). Whether these associations represent causal …