Background/objectives Physical activity (PA) protects against a wide range of diseases.
Habitual PA appears to be heritable, motivating the search for specific genetic variants that …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Background Higher circulating levels of the branched-chain amino acids (BCAAs; ie,
isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but …

Background: The implications of different adiposity measures on cardiovascular disease
etiology remain unclear. In this article, we quantify and contrast causal associations of …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …

BACKGROUND Obesity is caused by an imbalance between energy intake, ie eating and
energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide …

Obesity and diabetes now considered global epidemics. The prevalence rates of diabetes
are increasing in parallel with the rates of obesity and the strong connection between these …

The identification of genes and regulatory elements underlying the associations discovered
by GWAS is essential to understanding the aetiology of complex traits (including diseases) …