Purpose To determine the predictive power of computational fluid dynamics (CFD)-based
dispersion parameters in the development of a new inline DPI that is actuated with low …

The time-varying flow is studied experimentally in an anatomically accurate model of the
human airways from the mouth through several generations of bronchial branching. The …

Respiratory diseases have received increasing attention in recent decades. Airway
bifurcations are difficult regions to study, and computational fluid dynamics (CFD) offers an …

Respiratory tract deposition models provide a useful method for optimizing the design and
administration of inhaled pharmaceutical aerosols, and can be useful for estimating …

Inhalation of aerosols generated by electronic cigarettes leads to deposition of multiple
chemical compounds in the human airways. In this work, an experimental method to …

Aerosol delivery efficiency during noninvasive ventilation (NIV) is known to be low (~ 10%)
and is associated with poor outcomes of aerosol therapy. The objective of this study was to …

Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy
evaluations. This situation is expected to change in the future as the 3Rs principle, which …

Purpose: Delivering aerosols to the lungs through the nasal route has a number of
advantages, but its use has been limited by high depositional loss in the extrathoracic …

Numerical modelling using computational fluid mechanics (CFD) and discrete element
method (DEM) becomes increasingly prevalent for the exploration of agglomeration and …

The pulmonary route presents an attractive delivery pathway for topical treatment of lung
diseases. While significant progress has been achieved in understanding the physical …