New insights into the immunopathogenesis of systemic lupus erythematosus

GC Tsokos, MS Lo, PC Reis, KE Sullivan - Nature Reviews …, 2016 - nature.com
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity

C Carmona-Rivera, MJ Kaplan - Seminars in immunopathology, 2013 - Springer
Recent studies have renewed the interest on the potential role that neutrophils play in the
development of systemic lupus erythematosus (SLE) and other autoimmune conditions. A …

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

JS Knight, W Zhao, W Luo… - The Journal of …, 2013 - Am Soc Clin Investig
Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation
activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We …

B cell abnormalities in systemic lupus erythematosus and lupus nephritis—role in pathogenesis and effect of immunosuppressive treatments

DYH Yap, TM Chan - International journal of molecular sciences, 2019 - mdpi.com
Abnormalities in B cells play pivotal roles in the pathogenesis of systemic lupus
erythematosus (SLE) and lupus nephritis (LN). Breach in central and peripheral tolerance …

Neutrophils in the pathogenesis and manifestations of SLE

MJ Kaplan - Nature Reviews Rheumatology, 2011 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease of unclear etiology that
affects mostly women of childbearing age. Profound abnormalities in both innate and …

BNT162b2 vaccine-induced humoral and cellular responses against SARS-CoV-2 variants in systemic lupus erythematosus

Q Moyon, D Sterlin, M Miyara, F Anna… - Annals of the …, 2022 - ard.bmj.com
Objectives Our aim was to evaluate systemic lupus erythematosus (SLE) disease activity
and SARS-CoV-2-specific immune responses after BNT162b2 vaccination. Methods In this …

Precision medicine in systemic lupus erythematosus

S Fasano, A Milone, GF Nicoletti, DA Isenberg… - Nature Reviews …, 2023 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical
manifestations, ranging from restricted cutaneous involvement to life-threatening systemic …

From systemic lupus erythematosus to lupus nephritis: The evolving road to targeted therapies

M Xipell, GM Lledó, AC Egan, F Tamirou… - Autoimmunity …, 2023 - Elsevier
Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of
tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue …

[HTML][HTML] Neutrophil extracellular traps and systemic lupus erythematosus

Y Yu, K Su - Journal of clinical & cellular immunology, 2013 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by an
overproduction of autoantibodies. The loss of self-tolerance in SLE is believed to be caused …

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation

B Terrier, N Derian, Y Schoindre, W Chaara… - Arthritis research & …, 2012 - Springer
Introduction Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune
disease characterized by the appearance of autoantibodies, a global regulatory T cells …