The therapeutic landscape of tauopathies: challenges and prospects

JL Cummings, MI Gonzalez, MC Pritchard… - Alzheimer's Research & …, 2023 - Springer
Tauopathies are a group of neurodegenerative disorders characterized by the aggregation
of the microtubule-associated protein tau. Aggregates of misfolded tau protein are believed …

The spectrum of sleep disorders in Parkinson disease: a review

AC Lajoie, AL Lafontaine, M Kaminska - Chest, 2021 - Elsevier
There is increasing interest in the effects of sleep and sleep disturbances on the brain,
particularly in relation to aging and neurodegenerative processes. Parkinson disease (PD) …

Research progress on multiple cell death pathways of podocytes in diabetic kidney disease

C Yang, Z Zhang, J Liu, P Chen, J Li, H Shu, Y Chu… - Molecular …, 2023 - Springer
Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …

Risk of hospitalization and death associated with pimavanserin use in older adults with Parkinson disease

YJ Hwang, GC Alexander, H An, TJ Moore, HB Mehta - Neurology, 2021 - AAN Enterprises
Background and Objectives To determine the risk of hospitalization and death associated
with pimavanserin use. Methods We conducted a retrospective cohort study of adults 65 …

Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis

P Hu, K Li, XX Peng, Y Kan, TJ Yao, ZY Wang… - Frontiers in …, 2023 - frontiersin.org
It has been for thousands of years in China known medicinal homologous foods that can be
employed both as foods and medicines to benefit human and animal health. These edible …

Dihydroxy-metabolites of dihomo-γ-linolenic acid drive ferroptosis-mediated neurodegeneration

M Sarparast, E Pourmand, J Hinman… - ACS Central …, 2023 - ACS Publications
Even after decades of research, the mechanism of neurodegeneration remains
understudied, hindering the discovery of effective treatments for neurodegenerative …

Effects of manganese and iron, alone or in combination, on apoptosis in BV2 cells

Y Fang, C Gan, J Peng, Y Xie, H Song, Y Mo… - … Trace Element Research, 2024 - Springer
The aim of study was to address the effects of manganese and iron, alone and in
combination, on apoptosis of BV2 microglia cells, and to determine if combined exposure to …

Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer's Disease and Other Neurodegenerative Diseases

Y Sun, S Islam, M Michikawa, K Zou - International Journal of Molecular …, 2024 - mdpi.com
Presenilin, a transmembrane protein primarily known for its role in Alzheimer's disease (AD)
as part of the γ-secretase complex, has garnered increased attention due to its multifaceted …

Cytochrome c in cancer therapy and prognosis

J Pessoa - Bioscience Reports, 2022 - portlandpress.com
Cytochrome c (cyt c) is an electron transporter of the mitochondrial respiratory chain. Upon
permeabilization of the mitochondrial outer membrane, cyt c is released into the cytoplasm …

CMBA-SVM: a clinical approach for Parkinson disease diagnosis

B Sahu, SN Mohanty - International Journal of Information Technology, 2021 - Springer
Different intelligence models are used by researchers for an easy and successful diagnosis
of neurodegenerative diseases like Parkinson's disease (PD) but none of the adopted …