[HTML][HTML] Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy
Chronic liver disease (CLD) is a continuous process that causes a reduction of liver function
lasting more than six months. CLD includes alcoholic liver disease (ALD), non-alcoholic fatty …
lasting more than six months. CLD includes alcoholic liver disease (ALD), non-alcoholic fatty …
Unlocking the full potential of SGLT2 inhibitors: expanding applications beyond glycemic control
The number of diabetic patients has risen dramatically in recent decades, owing mostly to
the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic …
the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic …
Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: Novel insights on autophagy, apoptosis, and pyroptosis
R Abdelhady, S Saber… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that
demonstrates a dramatically increasing incidence worldwide. This study provides novel …
demonstrates a dramatically increasing incidence worldwide. This study provides novel …
Repurposing drugs targeting metabolic diseases for cancer therapeutics
Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …
The emerging role of metformin in the treatment of hepatocellular carcinoma: is there any value in repurposing metformin for HCC immunotherapy?
SP Papadakos, D Ferraro, G Carbone, AE Frampton… - Cancers, 2023 - mdpi.com
Simple Summary The study investigates the potential use of metformin, a medication
commonly prescribed for type 2 diabetes, in the treatment of hepatocellular carcinoma …
commonly prescribed for type 2 diabetes, in the treatment of hepatocellular carcinoma …
[HTML][HTML] Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling
S Saber, EE Abd El-Fattah, AM Abdelhamid… - Biomedicine & …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …
[HTML][HTML] Ganetespib (STA-9090) augments sorafenib efficacy via necroptosis induction in hepatocellular carcinoma: Implications from preclinical data for a novel …
Sorafenib, a multikinase inhibitor, is a first-line treatment for advanced hepatocellular
carcinoma, but its long-term effectiveness is limited by the emergence of resistance …
carcinoma, but its long-term effectiveness is limited by the emergence of resistance …
[HTML][HTML] Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis
Ulcerative colitis is an idiopathic disease that is widely incident worldwide. Canagliflozin,
antidiabetic agent, exhibited significant anti-inflammatory effects in a variety of animal …
antidiabetic agent, exhibited significant anti-inflammatory effects in a variety of animal …
Empagliflozin mediated miR-128-3p upregulation promotes differentiation of hypoxic cancer stem-like cells in breast cancer
LV Nalla, A Khairnar - European Journal of Pharmacology, 2023 - Elsevier
Abstract Aims The hsa-miR-128-3p expression is downregulated in advanced breast cancer
patients. Empagliflozin (EMPA) is an anti-diabetic drug with anticancer potential. The …
patients. Empagliflozin (EMPA) is an anti-diabetic drug with anticancer potential. The …
Carbocisteine as a modulator of Nrf2/HO-1 and NFκB interplay in rats: new inspiration for the revival of an old drug for treating ulcerative colitis
AM Abdelhamid, ME Youssef, S Cavalu… - Frontiers in …, 2022 - frontiersin.org
Ulcerative colitis (UC), an inflammatory bowel disease, is a chronic condition of a
multifaceted pathophysiology. The incidence of UC is increasing internationally. The current …
multifaceted pathophysiology. The incidence of UC is increasing internationally. The current …