The serotonin system is strongly implicated in the pathophysiology and therapeutic
alleviation of stress-related disorders such as anxiety and depression. Serotonergic …

It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …

Context Tryptophan depletion (TD) is a model used to study the contribution of reduced
serotonin transmission to the pathogenesis of major depressive disorder (MDD). Recent …

Early‐life events influence brain development and evoke long‐lasting behavioral
consequences. Postweaning social isolation in rodents induces emotional and …

The serotonergic (5-HT) system has been widely implicated in the pathophysiology of Major
Depressive Disorder (MDD). Although the 5-HT system is a popular target for drug therapy in …

Aberrant expression of the presynaptic serotonin 1A receptor (5-HT 1A-R) because of a
polymorphism in the 5-HT 1A-R gene is associated with severe depression in human …

Objective: We sought to demonstrate whether the specific activation of serotonin 1B (5-HT
1B) heteroreceptors by systemic or local administration of the selective 5-HT 1B receptor …

Backgrounds and aims Childhood obesity is increasing substantially across the world. The
World Obesity Federation (WOF) and World Health Organization (WHO) predicted that in …

Serotonin (5-HT), an important modulator of both sensory and motor functions in the
mammalian spinal cord, originates mainly in the raphe nuclei of the brainstem. However …

Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment
of generalized anxiety disorder in Humans. However, because only few animal models …