Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline were
first described more than three decades ago. Molecular cloning has resulted in the …

Objectives: The aim of this study was to determine whether cocaine's sympathomimetic
actions can be reversed by a potent centrally acting α2 adrenergic receptor (AR) agonist …

α-2 Adrenoceptors are important in baroreflex regulation. We tested the impact of α-2
adrenoceptors on heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS) …

We examined the relationship between age-associated lusitropic impairment, heart rate, and
Ca2+-handling proteins and assessed the efficacy of increasing left ventricular (LV) …

In an attempt to elucidate whether there is a specific α1-adrenergic receptor (α1-AR) subtype
involved in the genesis or maintenance of hypertension, the α1D-AR subtype was evaluated …

The central nervous system plays an important role in the minute-to-minute regulation of
arterial pressure, but its contribution to chronic regulation of arterial pressure is less clear. A …

Catecholamines induce direct vasoconstriction mediated by postsynaptic α-adrenergic
receptors (α-ARs) of both the α1 and α2 type. To evaluate the contribution of each α2-AR …

US 2006/OO73508 A1 Apr. 6, 2006 Related US Application Data Division of application No.
10/001073, filed on Nov. 1, 2001, now Pat. No. 7,041,810, and a continuation in-part of …

In a genome-wide scan in Scandinavians, we found suggestive linkage between early-onset
primary hypertension and a region on chromosome 2. The α2B-adrenoceptor gene, a …

Enhancing the selectivity of alpha2-adrenoceptor (α2A-AR) agonists remains an unresolved
issue. Herein, we reported the design of an α2A-AR agonist using the conformation …