N6-methyladenosine links RNA metabolism to cancer progression
Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …
development of antibody-based sequencing technologies and the findings of m6A-related …
Long non-coding RNA NEAT1: a novel target for diagnosis and therapy in human tumors
P Dong, Y Xiong, J Yue, SJB Hanley… - Frontiers in …, 2018 - frontiersin.org
The nuclear paraspeckle assembly transcript 1 (NEAT1, a long non-coding RNA) is
frequently overexpressed in human tumors, and higher NEAT1 expression is correlated with …
frequently overexpressed in human tumors, and higher NEAT1 expression is correlated with …
Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression
The importance of RNA methylation in biological processes is an emerging focus of
investigation. We report that altering m6A levels by silencing either N 6-adenosine …
investigation. We report that altering m6A levels by silencing either N 6-adenosine …
A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability
The human genome encodes thousands of long noncoding RNA (lncRNA) genes; the
function of majority of them is poorly understood. Aberrant expression of a significant …
function of majority of them is poorly understood. Aberrant expression of a significant …
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
RNA-binding proteins in cancer drug discovery
JB Bertoldo, S Müller, S Hüttelmaier - Drug discovery today, 2023 - Elsevier
RNA-binding proteins (RBPs) are crucial players in tumorigenesis and, hence, promising
targets in cancer drug discovery. However, they are largely regarded as 'undruggable' …
targets in cancer drug discovery. However, they are largely regarded as 'undruggable' …
[HTML][HTML] Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional
control of gene expression in several pathophysiological conditions. Diabetes adversely …
control of gene expression in several pathophysiological conditions. Diabetes adversely …
[HTML][HTML] The function and regulatory mechanism of RNA-binding proteins in breast cancer and their future clinical treatment prospects
X Lu, J Zhong, L Liu, W Zhang, S Zhao, L Chen… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is the most common female malignancy, but the mechanisms regulating gene
expression leading to its development are complex. In recent years, as epigenetic research …
expression leading to its development are complex. In recent years, as epigenetic research …
Drug delivery approaches for HuR-targeted therapy for lung cancer
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …
disease management have limitations associated with them. Novel therapeutic targets are …