During the last two decades, there has been broad interest in RNA-based technologies for
the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have …

Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …

In the last two decades, there has been growing interest in mRNA-based technology for the
development of prophylactic vaccines against infectious diseases. Technological …

Abstract mRNA vaccines have become a versatile technology for the prevention of infectious
diseases and the treatment of cancers. In the vaccination process, mRNA formulation and …

mRNA vaccine platforms present numerous advantages, such as versatility, rapid
production, and induction of cellular and humoral responses. Moreover, mRNAs have …

Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …

Background Although mRNA vaccines have been effective against multiple cancers, their
efficacy against pancreatic adenocarcinoma (PAAD) remains undefined. Accumulating …

Pancreatic cancer is characterized by inter-tumoral and intra-tumoral heterogeneity,
especially in genetic alteration and microenvironment. Conventional therapeutic strategies …

An important role of the immune system is in the surveillance for abnormal or transformed
cells, which is known as cancer immunosurveillance. Through this process, the first changes …

Abstract mRNA vaccines have gained popularity over the last decade as a versatile tool for
developing novel therapeutics. The recent success of coronavirus disease (COVID-19) …