Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Adoptive immunotherapy with T cells genetically modified to express chimeric antigen
receptors (CARs) is a promising approach to improve outcomes for cancer patients. While …

The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) isoenzymes are
responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors into Δ4 …

Adoptive T cell transfer therapy (ACT) using tumor infiltrating lymphocytes or lymphocytes
redirected with antigen receptors (CAR or TCR) has revolutionized the field of cancer …

Over the last few decades a wealth of evidence has been gathered on the potential role that
the immune system (IS) can play in the fight against cancer. Together with cell surface …

While progress has been made in treating primary epithelial tumors, metastatic tumors
remain largely incurable and still account for 85–90% of all cancer-related deaths …

In the past several years we demonstrated that the pineal neurohormone melatonin has
immunoenhancing properties and can counteract the immunodepres‐sion that may follow …

Background: The effects of metformin (MET) and curcumin (CUR) single treatments have
been tested against breast cancer; however, their combination has not been explored. Here …

We recently proposed that Th1 and Th2 cytokines exert opposite effects on the pathogenesis
and clinical outcome of organ-specific autoimmunity by altering the expression of genes …

Abstract Studies on Interlukin-4 (IL-4) disclosed great deal of information about its various
physiological and pathological roles. All these roles depend upon its interaction and …