Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …

Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …

Topoisomerases play a pivotal role in ensuring DNA metabolisms during replication,
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …

Naturally occurring or drug-induced DNA-protein crosslinks (DPCs) interfere with key DNA
transactions if not repaired in a timely manner. The unique family of DPC-specific proteases …

DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are
covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer …

DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain
of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both …

Apurinic/apyrimidinic (AP, or abasic) sites in DNA are one of the most common forms of DNA
damage. AP sites are reactive and form cross-links to both proteins and DNA, are prone to …

When a protein is covalently and irreversibly bound to DNA (ie, a DNA–protein cross-link
[DPC]), it may obstruct any DNA-based transaction, such as transcription and replication …

Proteins that act on DNA, or are in close proximity to it, can become inadvertently
crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs) …