This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Blood vessels are constantly exposed to hemodynamic forces in the form of cyclic stretch
and shear stress due to the pulsatile nature of blood pressure and flow. Endothelial cells …

The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow
patterns are important factors in atherosclerosis. Although disturbed flows in the branches …

The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …

Shear stress induces endothelial polarization and migration in the direction of flow
accompanied by extensive remodeling of the actin cytoskeleton. The GTPases RhoA, Rac1 …

The migration of endothelial cells (ECs) plays an important role in vascular remodeling and
regeneration. EC migration can be regulated by different mechanisms such as chemotaxis …

Endothelial cell alignment along the direction of laminar fluid flow is widely understood to be
a defining morphological feature of vascular homeostasis. While the role of associated …

The migration of vascular endothelial cells (ECs) is critical in vascular remodeling. We
showed that fluid shear stress enhanced EC migration in flow direction and called this …