Nucleotide binding oligomerization domain (NOD)-like receptors are cytoplasmic pattern-
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …

Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Protein import into mitochondria is a highly regulated process, yet how cells clear
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …

Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

In recent years, mitochondrial medicine has emerged as a new discipline resting at the
intersection of mitochondrial biology, pathology, and pharmaceutics. The central role of …

NLRs (nucleotide-binding domain leucine-rich repeat proteins or NOD-like receptors) are
regulators of inflammation and immunity. A subgroup of NLRs and the innate immune …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

A complex interaction exists between elements of the host innate immune system and viral
pathogens. It is essential that the host mount a robust immune response during viral …

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …