Pancreatic cancer is a deadly malignancy with limited treatment options. NLRX1 is a unique,
understudied member of the Nod-like Receptor (NLR) family of pattern recognition receptors …

LC3-associated phagocytosis (LAP) is an emerging non-canonical autophagy process that
bridges signaling from pattern-recognition receptors (PRRs) to autophagic machinery. LAP …

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal
tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal …

NLRX1, the mitochondrial NOD-like receptor (NLR), modulates apoptosis in response to
both intrinsic and extrinsic cues. Insights into the mechanism of how NLRX1 influences …

Uptake of glutamate from the extracellular space and glutamate release to neurons are two
major processes conducted by astrocytes in the central nervous system (CNS) that protect …

Histiocytic sarcoma is an uncommon malignancy in both humans and veterinary species.
Research exploring the pathogenesis of this disease is scarce; thus, diagnostic and …

Abstract NOD-like receptor (NLR) X1 (NLRX1) is an ubiquitously expressed inflammasome-
independent NLR that is uniquely localized in mitochondria with as yet unknown effects on …

The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …

Aspergillus fumigatus is an opportunistic fungal pathogen of immunocompromised patient
populations. Mortality is thought to be context-specific and occurs via both enhanced fungal …

Background Regulation of cell death during neurodegeneration is one of the key factors that
play a role in the speed at which a disease progresses. Out of several cellular pathways …