Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …

The microbiome plays a fundamental role in the maturation, function, and regulation of the
host-immune system from birth to old age. In return, the immune system has co-evolved a …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. Despite rapid advances over recent years …

Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …

Sex and aging influence the human immune system, resulting in disparate responses to
infection, autoimmunity, and cancer. However, the impact of sex and aging on the immune …