[HTML][HTML] Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …
The complexity of Alzheimer's disease: an evolving puzzle
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …
of the century to identify the components of pathological hallmarks and genetic subtypes and …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
[HTML][HTML] The epigenetics of Alzheimer's disease: factors and therapeutic implications
X Liu, B Jiao, L Shen - Frontiers in genetics, 2018 - frontiersin.org
Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer's disease
Z Shi, K Zhang, H Zhou, L Jiang, B Xie, R Wang… - Aging cell, 2020 - Wiley Online Library
Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some
tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD. The …
tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD. The …
Alzheimer's disorder: epigenetic connection and associated risk factors
The gene based therapeutics and drug targets have shown incredible and appreciable
advances in alleviating human sufferings and complexities. Epigenetics simply means …
advances in alleviating human sufferings and complexities. Epigenetics simply means …
[HTML][HTML] Epigenetic basis of lead-induced neurological disorders
T Wang, J Zhang, Y Xu - … journal of environmental research and public …, 2020 - mdpi.com
Environmental lead (Pb) exposure is closely associated with pathogenesis of a range of
neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …
neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …
[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease
J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …
threatens the health of the elderly and causes significant economic and social burdens. The …
[HTML][HTML] The associations of neutrophil–lymphocyte, platelet–lymphocyte, monocyte–lymphocyte ratios and immune-inflammation index with negative symptoms in …
M Šagud, Z Madžarac, G Nedic Erjavec… - Biomolecules, 2023 - mdpi.com
Neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte
ratio (MLR) and systemic immune-inflammation index (SII index) are increasingly used as …
ratio (MLR) and systemic immune-inflammation index (SII index) are increasingly used as …
[HTML][HTML] Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
M Xu, JY Zhu, XD Liu, MY Luo, NJ Xu - Translational Neurodegeneration, 2021 - Springer
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …
extensively applied to distinguish biological age from chronological age. Aging-related …