In Japan, intravenous alteplase, a recombinant tissue-type plasminogen activator (rt-PA),
was approved for an indication of ischemic stroke in 2005 on the basis of the results of a …

Background and Purpose—Intravenous thrombolysis (IVT) for stroke seems to be beneficial
independent of the underlying etiology. Whether this is also true for cervical artery dissection …

Carotid artery disease is common and increases the risk of stroke. However, there is wide
variability on the severity of clinical manifestations of carotid disease, ranging from …

Background and Purpose—In ischemic stroke, the site of arterial obstruction has been
shown to influence recanalization and clinical outcomes. However, this has not been studied …

Intravenous administration of tissue-type plasminogen activator (IV tPA) therapy has long
been considered a mainstay in ischemic stroke management. However, patients respond to …

Background and Purpose—The beneficial effect of intravenous thrombolytic therapy in
patients with acute ischemic stroke attributable to internal carotid artery (ICA) occlusion …

BACKGROUND AND PURPOSE: Internal carotid artery dissection is a common cause of
stroke in young adults. It may be responsible for tandem occlusion defined by a cervical …

Background: Ischemic strokes due to tandem occlusions (TOs) have poor outcomes if they
have been treated with only medical interventions. Recent trials demonstrated the …

Objective Acute tandem occlusions of the extracranial internal carotid artery (ICA) and a
major intracranial artery respond poorly to intravenous tissue plasminogen activator (tPA) …

BACKGROUND AND PURPOSE: The relationship between location of occlusion and
clinical outcome is poorly understood in patients receiving intravenous tissue-type …