Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

It is well established that early life environmental signals, including nutrition, set the stage for
long-term health and disease risk–effects that span multiple generations. This relationship …

Background Early puberty is a risk indicator for adult diseases. Identification of modifiable
causes of earlier puberty is, therefore, warranted. We estimate the association between …

Background: It remains unsettled whether prenatal exposure to perfluoroalkyl substances
(PFASs) affects human reproductive health through potential endocrine disruption …

Exposures to adverse conditions in utero can lead to permanent changes in the structure
and function of key physiological systems in the developing fetus, increasing the risk of …

Abstract STUDY QUESTION Do ART-conceived children have an increased risk for puberty
disorders? SUMMARY ANSWER Both ART-conceived boys and girls had a higher risk of …

Purpose This study investigated whether size at birth and infant growth were associated with
age of indicators of pubertal development in boys and girls. We hypothesized that restricted …

STUDY QUESTION Is there risk of selection bias in etiological studies investigating prenatal
risk factors of poor male fecundity in a cohort of young men? SUMMARY ANSWER The risk …

Background Season of birth has been associated with age at menarche. Maternal vitamin D
levels in pregnancy may explain this effect. We investigated whether the season of first …

Background Several studies have discovered an association between infant feeding
practices and puberty timing; however, most have involved female cohorts. We investigated …