Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

In this review we develop the argument that cholestatic liver diseases, particularly primary
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …

Defects in the function of cellular organelles such as peroxisomes, lysosomes and
mitochondria are well-known causes of human diseases. Recently, another organelle has …

The primary cilium, which was first so named by Sergei Sorokin (Sorokin, 1968), is a solitary
organelle that emanates from the cell surface of most mammalian cell types during growth …

Primary cilia are hair-like organelles and play crucial roles in vertebrate development,
organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory …

Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In
this review, we describe recent progress in the understanding of liver development with a …

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal
monogenic disorder. It has large inter-and intra-familial variability explained to a large extent …

Cholangiocytes are epithelial cells that line the intra-and extrahepatic ducts of the biliary
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …

This review focuses on the hypothesis that biliary HCO secretion in humans serves to
maintain an alkaline pH near the apical surface of hepatocytes and cholangiocytes to …