Dominantly inherited spinocerebellar ataxias (SCAs) are associated with phenotypes that
range from pure cerebellar to multisystemic. The list of implicated genes has lengthened in …

With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid,
finely granulated, digital health measures are highly warranted to augment clinical and …

Friedreichʼs ataxia (FA) is caused by a variant of the Frataxin (FXN) gene, leading to its
downregulation and progressively impaired cardiac and neurological function. Current gold …

Background Assessment of cerebellar ataxia has been confined to rating scales, gait
laboratories, and wearable sensors agnostic to patient input. Objectives The objective of this …

Background Quantitative assessment of severity of ataxia‐specific gait impairments from
wearable technology could provide sensitive performance outcome measures with high face …

Measures of step variability and body sway during gait have shown to correlate with clinical
ataxia severity in several cross‐sectional studies. However, to serve as a valid progression …

When brain damage occurs, gait and balance are often impaired. Evaluation of the gait
cycle, therefore, has a pivotal role during the rehabilitation path of subjects who suffer from …

Background The search for valid preclinical biomarkers of cerebellar dysfunction is a key
research goal for the upcoming era of early interventional approaches in spinocerebellar …

Background Clinical and regulatory acceptance of upcoming molecular treatments in
degenerative ataxias might greatly benefit from ecologically valid endpoints that capture …

The aim of this consensus paper is to discuss the roles of the cerebellum in human gait, as
well as its assessment and therapy. Cerebellar vermis is critical for postural control. The …