As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver malignancy with an
increasing incidence worldwide. Recently, histopathologic classification of small duct type …

Monocytes undergo phenotypic and functional changes in response to inflammatory cues,
but the molecular signals that drive different monocyte states remain largely undefined. We …

Aberrant pro-inflammatory activation of Kupffer cells (KCs) is strongly involved in the
pathogenesis of septic liver injury. Recent evidence indicates the crucial roles of excessive …

Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the
treatment of different types of cancers and the management of chronic inflammatory …

Tissue regeneration after body injury has always been a complex problem to resolve for
mammals. In adult mammals, the repair process after tissue injury is often accompanied by …

Macrophages are involved in hepatocyte steatosis and necroinflammation and play an
important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Impaired …

Background and Aims The Hippo pathway and its downstream effectors YAP and TAZ
(YAP/TAZ) are heralded as important regulators of organ growth and regeneration …

The excessive accumulation of bile acids (BA) in hepatocytes can trigger inflammatory
response and recruit macrophages, thereby accelerating cholestatic liver injury. The …

Macrophages are a heterogeneous population of innate immune cells and key cellular
components of the liver. Hepatic macrophages consist of embryologically-derived resident …